Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing in angiogenesis
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منابع مشابه
Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis.
Activator of G-protein signaling 8 (AGS8, also known as FNDC1) is a receptor-independent accessory protein for the Gβγ subunit, which was isolated from rat heart subjected to repetitive transient ischemia with the substantial development of collaterals. Here, we report the role of AGS8 in vessel formation by endothelial cells. Knockdown of AGS8 by small interfering RNA (siRNA) inhibited vascula...
متن کاملLEUNG et al ZEBRAFISH Gγ2 IN VEGF SIGNALING DURING ANGIOGENESIS HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Title: Zebrafish G protein γ2 is required for VEGF signaling during angiogenesis Bylines:
Vascular endothelial growth factor (VEGF) is a major mediator of pathological angiogenesis, a process necessary for the formation of new blood vessels to support tumor growth. Historically, VEGF is thought to signal via receptor tyrosine kinases, which are not typically considered to be G protein dependent. Here, we show that targeted knockdown of the G protein gng2 gene (Gγ2) blocks the normal...
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Vascular endothelial growth factor (VEGF) is a major mediator of pathologic angiogenesis, a process necessary for the formation of new blood vessels to support tumor growth. Historically, VEGF has been thought to signal via receptor tyrosine kinases, which are not typically considered to be G protein dependent. Here, we show that targeted knockdown of the G protein gng2 gene (G 2) blocks the no...
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Protein kinase D 1 (PKD-1) is a signaling kinase important in fundamental cell functions including migration, proliferation, and differentiation. PKD-1 is also a key regulator of gene expression and angiogenesis that is essential for cardiovascular development and tumor progression. Further understanding molecular aspects of PKD-1 signaling in the regulation of angiogenesis may have translation...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2016
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.181883